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You are here:Home » Antibodies » Antibodies-Transcription Factors, Homeobox (HOX) » Anti -Phox2b (Paired Mesoderm Homeobox Protein 2B, Neuroblastoma Phox, NBPhox, PHOX2B Homeodomain Protein, Paired-like Homeobox 2B, PMX2B)

Anti -Phox2b (Paired Mesoderm Homeobox Protein 2B, Neuroblastoma Phox, NBPhox, PHOX2B
Homeodomain Protein, Paired-like Homeobox 2B, PMX2B)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified IH
PHOX2B is a 33-35kD member of the paired homeobox family of transcription factors. It is not actually a mesoderm-associated protein, but is instead apparently restricted to neuronal precursors and mature neurons. It is found in glutamatergic neurons of the NTS and in neurons that demarcate the respiratory chemoreception pathway. In addition, PHOX2B is essential to the development of noradrenergic adrenal chromaffin and sympathetic motor neurons. Human PHOX2B is 314aa in length. It contains one DNA binding homeobox domain aa98-157 and two poly-Ala sequences, one between aa159-167 and another between aa241-260. Alanine extensions involving anywhere from 5 to 11 Ala residues may exist. These change the nature of the PHOX2B molecule. While wild-type PHOX2B is nuclear, Ala extensions promote its retention in the cytoplasm with loss of activity. PHOX2B may potentially form oligomers with itself, or it paralogue, PHOX2A. Human and mouse PHOX2B are identical in aa sequence
Catalog #P4079-03D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
Concentration~0.1mg/ml after reconstitution
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.2mg/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa1-94 from human PHOX2B expressed in E.coli.
SpecificityRecognizes human PHOX2B.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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