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You are here:Home » Antibodies » Abs to Oncoproteins » Anti -Pim2 (PIM-2, PIM2 Oncogene, PIM-2 Oncogene, HGNC-8987, Pim-2h, Proto-oncogene PIM2, Proto-oncogene PIM-2 Serine/threonine Kinase PIM2, Serine/threonine Kinase PIM-2)

Anti -Pim2 (PIM-2, PIM2 Oncogene, PIM-2 Oncogene, HGNC-8987, Pim-2h, Proto-oncogene PIM2,
Proto-oncogene PIM-2 Serine/threonine Kinase PIM2, Serine/threonine Kinase PIM-2)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
Pim2, a 311aa containing protein, belongs to a family of protooncogenes that encode serine/threonine protein kinases. Experiments carried out on knockout mice suggest that a deficiency in Pim2 leads to profound reduction of body size and non efficient proliferation of peripheral T lymphocytes. This enzyme not only regulates the stability of SOCS1 protein but has a role in phosphorylating the proapoptotic protein BAD on serine 112, which accounts in part for its ability to reverse Bad-induced cell death. Pim2 also has an important role in proliferating cells, cell life, cell cycle, and cell division as well as during meiosis. Pim2 is highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells.
Catalog #P4186-62E
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa189-206 of human Pim2 LHDEPYTDFDGTRVYSPP.
SpecificityRecognizes human Pim2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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