Anti -Pim2 (PIM-2, PIM2 Oncogene, PIM-2 Oncogene, HGNC-8987, Pim-2h, Proto-oncogene PIM2,
Proto-oncogene PIM-2 Serine/threonine Kinase PIM2, Serine/threonine Kinase PIM-2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E |
|
| Pim2, a 311aa containing protein, belongs to a family of protooncogenes that encode serine/threonine protein kinases. Experiments carried out on knockout mice suggest that a deficiency in Pim2 leads to profound reduction of body size and non efficient proliferation of peripheral T lymphocytes. This enzyme not only regulates the stability of SOCS1 protein but has a role in phosphorylating the proapoptotic protein BAD on serine 112, which accounts in part for its ability to reverse Bad-induced cell death. Pim2 also has an important role in proliferating cells, cell life, cell cycle, and cell division as well as during meiosis. Pim2 is highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. | | | Catalog # | P4186-62F | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to NGQKSHPMAMSQG, from the C-terminus of the protein sequence according-AAC78506. | | Specificity | Recognizes PIM2. Species sequence homology: human. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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