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You are here:Home » Biochemicals » Biochem-Antibiotics » Pimaricin (Natamycin, Antibiotic A 5283, Pimafucin)

Pimaricin (Natamycin, Antibiotic A 5283, Pimafucin)


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Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor.
Catalog #P4186-64
Source Streptomyces sp. MST-AS4274
Apperance Pale lemon solid
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number7681-93-8
Molecular FormulaC33H47NO13
Molecular Weight665.733
SourceStreptomyces sp. MST-AS4274
Purity~95% by HPLC
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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