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Anti -PIPMT, NT (Cap-specific Guanine-N2 Methyltransferase, Nuclear Receptor Coactivator 6-interacting Protein, PRIP-interacting Protein With Methyltransferase Motif, PIMT, Trimethylguanosine Synthase, CLL-associated Antigen KW-2, Hepatocellular Carcinoma-assoc
Anti -PIPMT, NT (Cap-specific Guanine-N2 Methyltransferase, Nuclear Receptor Coactivator
6-interacting Protein, PRIP-interacting Protein With Methyltransferase Motif, PIMT,
Trimethylguanosine Synthase, CLL-associated Antigen KW-2, Hepatocellular Carcinoma-assoc
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B |
|
| Nuclear receptor coactivators participate in the transcriptional activation of specific genes by nuclear receptors. PIPMT contains a 9aa methyltransferase motif I (VVDAFCGVG) and an invariant segment (GXXGXXI) found in K-homology motifs of many RNA-binding proteins. Immunofluorescence studies shows that PIPMT and PRIP proteins are colocalized in the nucleus. PIPMT binds 5-adenosyl-L-methionine, the methyl donor for the methyltransfer reaction, and it also binds RNA, suggesting that it is an RNA methyltransferase. Overexpression of PIPMT enhances the transcriptional activity of PPARG and RXR, and this enhancement is further stimulated by overexpression of PRIP, suggesting that PIPMT is a component of nuclear receptor signal transduction that acts through PRIP. | | | Catalog # | P4186-71 | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide selected from the N-terminal region of human PIPMT (KLH). | | Specificity | Recognizes human PIPMT. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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