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You are here:Home » Antibodies » Abs to Neurotrophins » Anti -Pleiotrophin (PTN, HARP, HBBM, Heparin Binding Growth-associated Molecule, HBGAM, Heparin Binding Growth Factor 8, HBGF8, Heparin Binding Neurite Outgrowth Promoting Factor 1, HBNF1, HBNF, Neurite Growth Promoting Factor 1, NEGF1, OSF1)

Anti -Pleiotrophin (PTN, HARP, HBBM, Heparin Binding Growth-associated Molecule, HBGAM,
Heparin Binding Growth Factor 8, HBGF8, Heparin Binding Neurite Outgrowth Promoting Factor
1, HBNF1, HBNF, Neurite Growth Promoting Factor 1, NEGF1, OSF1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP
Pleiotrophin (PTN) is the first member of a recently discovered family of developmentally regulated cytokines. This protein, previously designated heparin- binding growth factor-8, was renamed pleiotrophin to reflect its diverse activities (1). PTN is a member of a highly conserved human gene family of proteins. It has a high affinity for heparin and exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth (2). More recently, PTN was found to be overexpressed in a variety of neuroectodermal tumors and
described as an essential angiogenic growth factor in choriocarcinoma and melanoma, promoting metastatic growth. High expression levels of PTN were also found in patients with gastrointestinal malignancies, particularly in those patients with pancreatic cancer (3)
Applications:
Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Catalog #P4214-51
Recommended DilutionsWestern Blot: 1:100-1:10,000
Immunoprecipitation: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H495
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Pleiotrophin.
SpecificityRecognizes human Pleiotrophin. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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