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Anti -Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1)
Anti -Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC). | | | Catalog # | P4256-31B | | Applications | Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applilcations have not been tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Moleular Weight | Non-glycosylated PAI-1: 43kD | | Glycosylated PAI-1: 50kD | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 6F220 | | Host | Mouse | | Source | Human | | Concentration | ~3mg/ml | | Form | Supplied in liquid in PBS, pH 7.4. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant human PAI-1 | | Specificity | Recognizes human PAI-1 and exhibits inhibitory characteristics. Binds to an epitope localized to the F-Helix of PAI-1. The PAI-1/mab complex acts as a substrate for its target proteinases tPA and uPA. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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