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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1)

Anti -Plasminogen Activator Inhibitor Type 1, inhibitory (PAI-1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angoigenisis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC).
Catalog #P4256-31B
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other applilcations have not been tested.
Recommended DilutionsOptimal dilutions to be determined by the researcher.
Moleular WeightNon-glycosylated PAI-1: 43kD
Glycosylated PAI-1: 50kD
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6F220
HostMouse
SourceHuman
Concentration~3mg/ml
FormSupplied in liquid in PBS, pH 7.4.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant human PAI-1.
SpecificityRecognizes human PAI-1 and exhibits inhibitory characteristics. Binds to an epitope localized to the F-Helix of PAI-1. The PAI-1/mab complex acts as a substrate for its target proteinases tPA and uPA. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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