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You are here:Home » Antibodies » Abs to Protease Inhibitors » Anti -Plasminogen Activator Inhibitor Type 1 (PAI-1, Clade E, Endothelial plasminogen activator inhibitor, Nexin, PLANH1, Serine (or cysteine) proteinase inhibitor, Serpin peptidase inhibitor clade E, Serpine1 antibody)

Anti -Plasminogen Activator Inhibitor Type 1 (PAI-1, Clade E, Endothelial plasminogen
activator inhibitor, Nexin, PLANH1, Serine (or cysteine) proteinase inhibitor, Serpin
peptidase inhibitor clade E, Serpine1 antibody)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E IH RIA
Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC).
Catalog #P4256-32L
ApplicationsSuitable for use in ELISA, RIA and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (frozen): 1:50-1:100
Immunohistochemistry (paraffin): 1:50. Recommend pretreatment with 0.05% Pronase E for 20 minutes.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Reconstitute with 20ul ddH2O.
PuritySerum
ImmunogenPurified human PAI-1
SpecificityRecognizes human Plasminogen Activator Inhibitor 1. No cross reactivities observed with human tPA, uPA and PAI-2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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