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You are here:Home » Antibodies » Abs to Coagulation Factors » Anti -Plasminogen Activator Inhibitor Type 1 (PAI 1)

Anti -Plasminogen Activator Inhibitor Type 1 (PAI 1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH
Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angoigenisis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC).
Catalog #P4256-34J
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 10ug/ml
Optimal dilutions to be determined by the researcher.
HybridomaNSO cells with spleen cells from BALB/c mouse
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No5F119
HostMouse
SourceHuman
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 0.02% sodium azide. Reconstitute with 500ul sterile ddH2O.
PurityPurified by Protein G affinity chromatography.
ImmunogenPAI from human melanoma cell line MJZJ.
SpecificityRecognizes human active PAI-1, latent PAI-1, inactive PAI-1 and t-PA-PAI-1 complexes. Does not recognize PAI-2 or PAI-3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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