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Anti -Plasminogen Activator Inhibitor Type 1 (PAI 1)
Anti -Plasminogen Activator Inhibitor Type 1 (PAI 1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E IH |
|
| Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angoigenisis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation. The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer. PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration. This binding has proven to be an important inhibitor of the activated form of protein C (APC). | | | Catalog # | P4256-34J | | Applications | Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Immunohistochemistry: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Hybridoma | NSO cells with spleen cells from BALB/c mouse | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1,k | | Clone No | 5F119 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml (after reconstitution) | | Form | Supplied as a lyophilized powder from PBS, pH 7.4, 0.02% sodium azide. Reconstitute with 500ul sterile ddH2O. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | PAI from human melanoma cell line MJZJ. | | Specificity | Recognizes human active PAI-1, latent PAI-1, inactive PAI-1 and t-PA-PAI-1 complexes. Does not recognize PAI-2 or PAI-3. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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