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You are here:Home » Biochemicals » Biochem-Antibiotics » Platensimycin

Platensimycin

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Specifications

Platensimycin is a novel broad spectrum Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by target-based whole-cell screening strategy using an antisense differential sensitivity assay based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase FabF of the fatty acid synthesis pathway.
Catalog #P4262-20
SourcePlatensimycin
Molecular Weight~441.2
SolubilitySoluble in ethanol, methanol, DMF or DMSO.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number835876-32-9
Molecular FormulaC24H27NO7
Molecular Weight441.2
SourceStreptomyces sp. MST-AS5989
Purity95% by HPLC
FormSupplied as a white to buff solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.


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