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Abs to Plastin
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Anti -Plastin L (PLSL, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1, LCP-1, Plastin 2, Plastin-2)
Anti -Plastin L (PLSL, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1, LCP-1,
Plastin 2, Plastin-2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B IP IF |
|
| L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calciumbinding domains. It is phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosteronse in androgen receptor positive prostrate and breast cancer cells, through three androgen receptor binding elements, located in the upstream region of the gene. | | | Catalog # | P4268-02 | | Applications | Suitable for use in Immunoprecipitation, Western Blot and Immunofluorescence. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml for 2h, RT | | Immunoprecipitation: 2ug/mg protein lysate | | Optimal dilutions to be determined by the researcher. | | Positive Control | Human polymorphonuclear neutrophils, monocytes, MCF-7, Jurkat cells | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | SPM414 | | Host | Mouse | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. | | Purity | Purified by Protein G affinity chromatography. | | Immunogen | Recombinant coresponding to L-plastin. | | Specificity | Recognizes human L-plastin. Does not react with rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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