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You are here:Home » Antibodies » Abs to Plastin » Anti -Plastin L (PLSL, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1, LCP-1, Plastin 2, Plastin-2)

Anti -Plastin L (PLSL, L-Plastin, LC64P, Lymphocyte Cytosolic Protein 1, LCP1, LCP-1,
Plastin 2, Plastin-2)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IP IF
L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calciumbinding domains. It is phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosteronse in androgen receptor positive prostrate and breast cancer cells, through three androgen receptor binding elements, located in the upstream region of the gene.
Catalog #P4268-02
ApplicationsSuitable for use in Immunoprecipitation, Western Blot and Immunofluorescence. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml for 2h, RT
Immunoprecipitation: 2ug/mg protein lysate
Optimal dilutions to be determined by the researcher.
Positive ControlHuman polymorphonuclear neutrophils, monocytes, MCF-7, Jurkat cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone NoSPM414
HostMouse
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant coresponding to L-plastin.
SpecificityRecognizes human L-plastin. Does not react with rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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