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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -Plexin A1

Anti -Plexin A1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IC
Plexin A1 is an ~200kD type I transmembrane member of the Plexin family of Semaphorin signal transducers. It consists of a 1218aa extracellular domain with one Sema domain, a spacer, and four tandem IPT/TIG domains, a 21aa transmembrane segment, and a 631aa cytoplasmic domain. Plexin A1 binds the transmembrane Semaphorin 6D directly and binds the Class 3 secreted Semaphorins indirectly via Neuropilin-1 and -2. It mediates cytoskeletal remodeling that results in cell migration and axon repulsion. Within aa964-1152 (in the IPT/TIG region), human Plexin A1 shares 93aa sequence identity with mouse and rat Plexin A1.
Catalog #P4271-10B
ApplicationsSuitable for use in Western Blot and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunocytochemistry: 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11n153
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa986-1152 from human Plexin A1 expressed in E. coli (Q9UIW2).
SpecificityRecognizes human Plexin A1. Does not react with recombinant human Plexin A4, B1, B2, B3, C1, D1, recombinant mouse Plexin A1, A2, A3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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