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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -Plexin A4

Anti -Plexin A4

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B
Plexin A4 is a 195kD member of the plexin A subfamily, plexin family of proteins. It is found on sensory, autonomic and motor neurons, plus T and dendritic cells. Plexin A4 negatively regulates cell migration, activation and axon guidance, and does so by serving as a receptor for Sema6A and 6B, and as a co-receptor with neuropilin-1 and -2 for Sema3A. Mature human Plexin A4 is an 1871aa type I transmembrane glycoprotein. It contains a 1214aa extracellular domain (ECD) and a 636aa cytoplasmic region. The ECD contains one Sema-domain (aa51-482), three PSI domains (aa509-856) and four IPT regions (aa858-1230) that contain a phosphoserine at #946. There are three isoform variants. One shows a 65aa substitution for (aa458-1894), a second shows an 80aa substitution for (aa1292-1894), and a third shows the just mentioned 80aa substitution coupled to a 14aa substitution for (aa1-535). Over (aa24-1237), human Plexin A4 is 97% aa identical to mouse Plexin A4.
Catalog #P4271-17
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionDirect ELISA: 0.5-1.0ug/ml
Western Blot: 1.0ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceGoat
ConcentrationNot determined
FormSupplied as a lyophilized powder form PBS with 5% trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to human Plexin A4 expressed in CHO cells (Q9HCM2).
SpecificityRecognizes human Plexin A4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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