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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -Plexin A4 (PLXNA4, KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003) (PE)

Anti -Plexin A4 (PLXNA4, KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
Plexin A4 is a 220-230kD member of the plexin A subfamily of plexin family proteins. It is found on sensory, autonomic, and motor neurons, oligodendrocytes, T cells, and dendritic cells. Plexin A4 regulates cell migration, activation, and axon guidance via repulsion. It serves as a receptor for transmembrane semaphorins, Semaphorin 6A and 6B, and as a co-receptor with Neuropilin-1 for the secreted semaphorin, Semaphorin 3A. During development, it plays a role in nerve migration and midline crossing and down regulates dendrite formation. It is often co-expressed with Plexin A3, which can also engage class 6 semaphorins, but prefers Semaphorin 3F/Neuropilin-2 to Semaphorin 3A/Neuropilin-1. Thus, Plexins A3 and A4 are redundant in some functions, but unique in others. In T cells, Plexin A4 engages Semaphorin 3A and negatively regulates TCR signals. The extracellular domain of human Plexin A4 shares 97% aa identity with mouse, equine, canine, and bovine Plexin A4.
Catalog #P4271-18
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Excitation 488nm
Emission 565-605nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No12K164
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to human Plexin A4 expressed in CHO cell line.
SpecificityRecognizes human Plexin A4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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