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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (PE)

Anti -PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
PLXNB1 is a 300kD member of the B subfamily, plexin family of semaphorin receptors. Mature human PLXNB1 is a 2116aa type I transmembrane (TM) glycoprotein that contains a 1471aa extracellular domain (ECD) and a 612aa cytoplasmic region. The ECD contains one semaphorin domain, two PSI domains, and three IPT repeats. The ECD is cleaved into two subunits, a 200kD a-chain (aa20-1305) and a 100kD TM b-chain. The subunits are nondisulfide-linked and generate a high-affinity receptor. PLXNB1 is a receptor for CD100/Sema4D. It forms a receptor complex with neuropilins, MET, and EGFR2. Multiple splice variants are known. One shows a deletion of aa689-871. A second shows a 53aa substitution for aa677-2135. And a third shows a 53aa substitution for the 53aa between aa677-729. Over aa35-150, human PLXNB1 is 90% and 97% aa identical to dog and mouse PLXNB1, respectively.
Catalog #P4271-28B
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionsFlow Cytometry: 10ul labels 10e6 cells. Validated for use with Jurkat cells.
Optimal dilutions to be determined by the researcher.
HybridomaFusion of a mouse myeloma with B cells obtained from a mouse immunized with NS0 cells transfected with human PLXNB1.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG1
Clone No10K24
HostMouse
SourceHuman
Concentration~0.025mg/ml
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0 cells transfected with aa1-2135 from isoform 1 of human PLXNB1 (O43157).
SpecificityRecognizes human PLXNB1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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