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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -Plexin D1 (Plexin-D1, PLXND1, KIAA0620) (PE)

Anti -Plexin D1 (Plexin-D1, PLXND1, KIAA0620) (PE)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified FC
Plexin D1 is a type I transmembrane protein that is the prototype of the Plexin D subfamily in the Plexin family. It is expressed on multiple tissues including fetal neuronal and endothelial cells. Plexin D1 expression is also induced on tumor vasculature and tumor cells. The 1879aa mature human Plexin D1 contains a large extracellular domain 1225aa with a 500aa sema domain and three short MRS (Met-related sequences) cysteine-rich motifs. By alternative splicing, multiple Plexin-D1 isoforms may exist. Plexin D1 binds Sema4A to suppress angiogenesis. It also binds Sema3E directly to mediate repulsive vascular vessel guidance. In mouse, this interaction has been shown to be independent of Neuropilin and Sema3A. Over the extracellular region used as an immunogen, human Plexin D1 shares 89% and 91% aa identity with the mouse and canine protein.
Catalog #P4271-45E
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Excitation 488nm
Emission 565-605nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa47-1271 from human Plexin D1 to extracellular domain.
SpecificityRecognizes human Plexin D1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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