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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -PML, Sumoylation Site (Probable Transcription Factor PML, Tripartite Motif-containing Protein 19, RING Finger Protein 71, MYL, RNF71, TRIM19)

Anti -PML, Sumoylation Site (Probable Transcription Factor PML, Tripartite
Motif-containing Protein 19, RING Finger Protein 71, MYL, RNF71, TRIM19)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL).
Catalog #P4296-06C
ApplicationsSuitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide PRKVIKMESEEGKEA containing a predicted sumoylation site from the central region of human PML (KLH).
SpecificityRecognizes human PML.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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