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You are here:Home » Antibodies » Abs to Myelin » Anti -PMP 22 (Peripheral Myelin Protein)

Anti -PMP 22 (Peripheral Myelin Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. However, Schwannoma cells not associated with peripheral nerve will be negative. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot- Marie-Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies. PMP-22 has recently been reported in high-grade osteosarcoma.
Catalog #P4305-03
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry: (Formalin/paraffin): 1:12.5-1:25 for 60 min. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Positive ControlPeripheral nerve, pancreatic islets.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.2% BSA and 15mM sodium azide, before the addition of glycerol to 40%.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide from near C-terminal of human PMP-22. Epitope
SpecificityRecognizes human PMP-22.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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