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You are here:Home » Antibodies » Abs to Myelin » Anti -PMP22 (Peripheral Myelin Protein 22, PMP-22, Growth Arrest-specific Protein 3, GAS-3, GAS3)

Anti -PMP22 (Peripheral Myelin Protein 22, PMP-22, Growth Arrest-specific Protein 3,
GAS-3, GAS3)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
PMP 22 (Peripheral Myelin Protein) is a 22kD glycoprotein, expressed in the compact myolin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot- Marie-Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies.
Catalog #P4305-04C
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 1:50 for 10min at RT
Staining of formalin-fixed tissues requires boiling tissues sections in 10mM citrate buffer, pH 6.0, for 10min followed by cooling at RT for 20min
Optimal dilutions to be determined by the researcher.
Positive ControlPancreas
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide from near the C-terminus of human PMP22.
SpecificityRecognizes human PMP22.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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