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You are here:Home » Antibodies » Antibodies-Myelin » Anti -Peripheral Myelin Protein 22 (PMP22, Growth arrest-specific protein 3, Gas-3)

Anti -Peripheral Myelin Protein 22 (PMP22, Growth arrest-specific protein 3, Gas-3)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Myelin protein zero (P0) is the most abundant protein in mammalian peripheral nerve myelin. An interaction between P0 and PMP22 has been detected in compact myelin. Defects in PMP22 have been related to Charcot-Marie-Tooth disease (CMT) and inflammatory demyelinating neuropathy (IDP). Immunization with PMP22 induces experimental auto-immune neuritis without central nervous inflammation. Therefore, PMP22 is considered as candidate auto-antigen in inflammatory diseases of the peripheral nervous system, including both acute and chronic inflammatory demyelinating polyradiculoneuropathy.
Catalog #P4305-05
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and ELISA. Other aplications not tested.
Recommended DilutionsWestern Blot: 1:50
Immunohistochemistry: Paraffin embedded sections
Optimal dilutions to be determined by researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone NoCF1
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa121-133 in the second extracellular domain of human PMP2 with an extra N-terminal cysteine residue, CRHPEWHLNSDYSYG.
SpecificityRecognizes human peripheral myelin protein 22 (PMP22). Species Crossreactivity: Rhesus monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPeripheral Myelin Protein 22, Growth arrest-specific protein 3, Gas-3

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