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You are here:Home » Antibodies » Abs to DNA Replication, Repair » Anti -PMS2 (PMS2 Postmeiotic Segregation Increased 2, PMS-2, DNA Mismatch Repair Gene Homolog, H_DJ0042M02.9, HNPCC4, PMS1 Protein Homolog 2, PMS2CL, PMSL2) (Agarose)

Anti -PMS2 (PMS2 Postmeiotic Segregation Increased 2, PMS-2, DNA Mismatch Repair Gene
Homolog, H_DJ0042M02.9, HNPCC4, PMS1 Protein Homolog 2, PMS2CL, PMSL2) (Agarose)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit IP
Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially bunds to mismatched DNA. This is followed by binding of the MutH endonuclease and MutL to form a complex that carries out excision repair. The hMSH2 gene specifies a MutS homologue and hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are associated with hereditary nonpolyposis colon cancer (HNPCC), one of the most common hereditary diseases in man. As with the bacterial system, HNPCC is characterized by frequent microsatellite mutations that arise by somatic mutation due to a replication error (RER+) phenotype. Both hPMS1 and hPMS2 are mutated in the germline of HNPCC patients. Although the exact function of MutL and its homologs has yet to be determined, it is known that a complex of PMS2 and MLH1 (MutLa) from HeLa cells can complement a deficiency of MLH1 in hypermutable H6 colorectal tumor cells.
Catalog #P4320-11A
ApplicationsSuitable for use in Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormAs reported
PurityAs reported
ImmunogenA synthetic peptide, which represented a portion of human Post Meiotic Segregation Increased 2 encoded within exon 2 (LocusLink ID 5395).
SpecificitySpecific for human PMS2. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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