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You are here:Home » Biochemicals » Biochem-Antibiotics » Polymyxin B (PMB) (Biotin)

Polymyxin B (PMB) (Biotin)

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Specifications

The peptide Polymyxin B (PMB) is a cyclic amphipathic peptide antibiotic that binds to endotoxins (lipopolysaccharide, LPS). Binding of PMB to LPS results in neutralization of LPS of gram-negative bacteria. For the study of PMB-LPS interactions PMB conjugates proved to be superior to the application of anti-PMB antibodies. PMB conjugates are useful general probes to detect or measure lipid A and LPS of various species using simple methods. These conjugates are also useful for staining of bacteria. The conjugates obviate the need for many specific antisera. Furthermore PMB conjugates are useful tools in investigations of LPS binding protein (LBP) and bactericidal permeability increasing protein (BPI) interactions with LPS. In conclusion, PMB conjugates are useful probes for endotoxin research.
Catalog #P4400-15B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended Dilutions ELISA: 1:50
Optimal dilution determined by the researcher
Storage and StabilityLyophilized powder may be stored at -20°C. Reconstitute with sterile ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PurityPurified
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 0.1% BSA and 0.02% 2-chloroacetamide. Labeled with Biotin. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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