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You are here:Home » Antibodies » Abs to Antibiotics » Anti -Polymyxin B

Anti -Polymyxin B

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E B
The peptide antibiotic Polymyxin B (PMB) binds to bacterial endotoxin (lipopolysaccharide, LPS). The interaction of PMB with LPS involves ionic forces between amino groups in PMB and negatively charged phosphate and carboxyl groups in the lipid A-Kdo region. PMB has relevance for endotoxin research in at least two ways: first, PMB reacts with LPS of many species regardless of varied serospecificity, and thus it can be used as a general probe for measuring or detecting LPS or lipid A. Second, binding of PMB to LPS may result in neutralization of the detrimental effects of LPS either in vitro or in vivo. Monoclonal antibody enables the possibilities to study quantitatively the interaction of PMB and LPS.
Catalog #P4400-15C
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypeMonoclonal
IsotypeIgM
Clone No9G252
HostMouse
ConcentrationNot determined.
FormSupplied as a liquid, 0.02% sodium azide.
PuritySupernatant
ImmunogenWhole bacteria of the Re chemotype of S. minnesota
SpecificityRecognizes Polymyxin B. Binds to free Polymyxin B as well as to Polymyxin B already bound to LPS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesPMB


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