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Abs to Transcription Factors, Homeobox (HOX)
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Anti -POU Domain, Class 2, Transcription Factor 1 (POU2F1, POU Class 2 Homeobox 1, NF-A1, Octamer-binding Transcription Factor 1, OCT1, OCT-1, OTF1, OTF-1)
Anti -POU Domain, Class 2, Transcription Factor 1 (POU2F1, POU Class 2 Homeobox 1, NF-A1,
Octamer-binding Transcription Factor 1, OCT1, OCT-1, OTF1, OTF-1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
B |
|
| Oct-1 is a 90kD transcription factor that binds to the octamer motif ATTTGCAT. This ubiquitous regulatory element is most conspicuous in B cells, where it is found in every immunoglobulin (Ig) promoter and in most Ig enhancers. In addition, Oct-1 binding also activates the promoters of the genes for some small nuclear RNAs (snRNA) and for histone H2B. Oct-1 protein is expressed in multiple tissues although some Oct-1 isoforms appear to be tissue specific and the homologous Oct-2 appears to the Oct proteins bind to DNA together with another protein transcription factor, octamer binding factor-1 (OBF-1), to form a ternary complex. Evidence suggests that regulation of Oct family transcription factors occurs at the level of phosphorylation. | | | Catalog # | P5250-01F1 | | Applications | Suitable for use in Western Blot. Not suitable for Immunoprecipitation or Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Hybridoma | Sp2/0 myeloma cells with spleen cells from Balb/c mice. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11n156 | | Host | Mouse | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in 100ul PBS, pH 7.2, 50% glycerol. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant corresponding to Oct-1. | | Specificity | Recognizes human Oct-1. Species Crossreactivity: mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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