Anti -PPARg (Peroxisome Proliferator Activated Receptor gamma, PPAR-gamma, PPARG1, PPARG2,
PPARG3, HUMPPARG, Nuclear Receptor Subfamily 1 Group C Member 3, NR1C3, PAX8/PPARG Fusion
Gene)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IC IF |
|
| Peroxisome proliferator-activated receptors (PPAR) are members of the steroid nuclear receptor superfamily (1). The mammalian PPARs include three subtypes PPARalpha, PPARbeta, and PPARgamma. PPARs have been found to regulate fatty acid oxidation, fat cell development, lipoprotein metabolism, and glucose homeostasis (2). Recent studies have found that PPARs can affect the pathogenesis and development of tumors (3). PPARgamma and PPARbeta have been specifically implicated in tumorigenesis (3). PPARalpha is the focus of research studying its function in fatty acid beta-oxidation, lipid metabolism, and vascular inflammation (4). PPARbeta also plays a key role in the activation of keratinocytes during the inflammatory reaction associated with a skin injury (5). Of the three subtypes of PPARs, PPARgamma is the most widely studied. PPARgamma has been implicated in various human chronic diseases such as diabetes mellitus, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, and Alzheimer s disease (6). | | | Catalog # | P5505-06D | | Applications | Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:400 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a liquid in PBS, 0.2% gelatin, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the C terminus of human PPAR gamma. Cellular Localization: Nuclear. | | Specificity | Recognizes both human PPARgamma1 and PPARgamma2. Species Crossreactivity: mouse, rat, bovine, chicken, canine, hamster and porcine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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