Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Retinoblastoma Proteins » Anti -PRDM2 (PR Domain Containing Protein 2, G3B, KMT8, MTE-binding Protein, MTB-ZF, PR Domain Zinc Finger Protein 2, PR-domain Zinc Finger Protein 2, Retinoblastoma Protein-binding Zinc Finger Protein, Retinoblastoma Protein-interacting Zinc-finger Protein, RI

Anti -PRDM2 (PR Domain Containing Protein 2, G3B, KMT8, MTE-binding Protein, MTB-ZF, PR
Domain Zinc Finger Protein 2, PR-domain Zinc Finger Protein 2, Retinoblastoma
Protein-binding Zinc Finger Protein, Retinoblastoma Protein-interacting Zinc-finger
Protein, RI

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
PRDM2, also known as RIZ1, is a nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C- terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. RIZ1 is a tumor suppressor gene, and RIZ1 inactivation is commonly found in many types of human cancers. RIZ1 inactivation most frequently occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, or missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
Catalog #P5750-10B
ApplicationsSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:1000
Immunohistochemistry: 1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding the C-terminal region of human PRDM2 (KLH). Cellular Localization: Nucleus.
SpecificityRecognizes human PRDM2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links