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You are here:Home » Antibodies » Abs to Retinoblastoma Proteins » Anti -PRDM2 (PR Domain Containing Protein 2, G3B, KMT8, MTE-binding Protein, MTB-ZF, PR Domain Zinc Finger Protein 2, PR-domain Zinc Finger Protein 2, Retinoblastoma Protein-binding Zinc Finger Protein, Retinoblastoma Protein-interacting Zinc-finger Protein, RI

Anti -PRDM2 (PR Domain Containing Protein 2, G3B, KMT8, MTE-binding Protein, MTB-ZF, PR
Domain Zinc Finger Protein 2, PR-domain Zinc Finger Protein 2, Retinoblastoma
Protein-binding Zinc Finger Protein, Retinoblastoma Protein-interacting Zinc-finger
Protein, RI

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
PRDM2, a member of nuclear:histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280kD RIZ1 containing PR-domain and a 250kD truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.
Catalog #P5750-10C
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum.
ImmunogenSynthetic peptide corresponding to aa1098-1115 (ISFKQEELENEGLKPREE) of human PRDM2 (isoform a).
SpecificityRecognizes human PRDM2. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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