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Anti -PRDM7 (Probable Histone-lysine N-methyltransferase PRDM7, PR Domain Zinc Finger Protein 7, PR Domain-containing Protein 7, PFM4)
Anti -PRDM7 (Probable Histone-lysine N-methyltransferase PRDM7, PR Domain Zinc Finger
Protein 7, PR Domain-containing Protein 7, PFM4)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
E |
|
| It belongs to the family of PRDM protein family and contains a PR domain and 5 Kruppel Like-zinc finger motifs at the C-terminal region. It plays a pivotal role in inducing and regulating terminal differentiation of B-lymphocytes. It recruits HDAC and complex of Groucho/TLE family proteins to the DNA and actively represses vital genes required for B-cell proliferation including c-myc, CIITA promoter III, CD23b and PAX-5 promoter. PRDM1 silences IFNâ-gene expression by binding specifically to PRDI of the IFNâ gene promoter. It is continuously expressed in all Plasma cells, but is not detected in early bone marrow B-cells, memory B-cells in spleen and most germinal center B-cells. In myeloma cells, PRDI-BF1â, a truncated isoform of PRDM1 is expressed that has an impaired ability to repress transcription suggesting a clinical implication. | | | Catalog # | P5750-45C | | Applications | Suitable for use in ELISA. Other applications not tested. | | Recommended Dilution | ELISA: 1:100-1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.025% sodium azide, 50% glycerol. | | Purity | Serum. | | Immunogen | Synthetic peptide corresponding to aa389-403 (LLIHQRTHRGEAPVC) of human PRDM7. | | Specificity | Recognizes human PRDM7, isoform A (NP_443722). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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