Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications Monoclonal Rat Supernatant E B IP IH

Immunohistochemical studies of control brains revealed that PS1 is expressed primarily in neurons, with the protein localizing in the soma and dendritic processes. In contrast in FAD and sporadic Alzheimer’s disease cases, PS1 immunoreactivity was present in the neuritic component of senile plaques as well as in neurofibrillary tangles. Localization of PS1 immunoreactivity in familial and sporadic Alzheimer’s disease suggest that genetically heterogeneous forms of the disease share a common pathophysiology involving PS1 protein.
Catalog #	P6300-35C
Applications	Suitable for use in Immunohistochemistry, Immunoblot, Immunoprecipitation and ELISA. Other applications not tested.
Recommended Dilutions	Immunoblot: 1:250-1:500. Recommend blocking buffer is TBS containing 5% non fat milk and 0.01% Tween 20. It is recommended that you also dilute the antibody in this blocking buffer. Incubate for 1 to 2 hours at RT or overnight at 4°C.
	Optimal dilutions to be determined by researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone Type	Monoclonal
Isotype	Ig
Clone No	2Q127
Host	Rat
Source	Human
Concentration	Not determined
Form	Liquid containing 0.1% sodium azide.
Purity	Culture supernatant from hollow fiber system
Immunogen	A fusion protein antigen containing the N-terminal of human PS-1 (residues 21-80) fused to GST.
Specificity	Recognizes human Presenilin 1.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.