Anti -PRMT5 (SKB1 homolog, HMT1 hnRNP methyltransferase-like 5, SKB1Hs, SKB1, JBP1, IBP72,
HRMT1L5, protein arginine methyltransferase 5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT5, also known as Janus kinase-binding protein 1 (JBP1) and Skb1Hs (human homolog of Skb1 of fission yeast can catalyze the formation of mega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine in a variety of proteins. Recombinant PRMT5 can mono and dimethylate histone 2A and myelin basic protein. PRMT5 appears to have lower specific enzyme activity than PRMT1. | | | Catalog # | P9004-26A | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:16000 | | Western Blot: 1-3ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid 0.5mg/ml Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA. | | Purity | Purified from goat serum by ammonium sulfate precipitation followed by antigen affinity chromatography using the immunizing peptide. | | Immunogen | Synthetic peptide corresponding to RACREKDRDPEAQ, from the internal region of the protein sequence according to (NP_006100.2; NP_001034708.1.). | | Specificity | Recognizes human PRMT5. Sequence Homology: mouse, rat, bovine, porcine, canine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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