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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -PRMT5 (SKB1 homolog, HMT1 hnRNP methyltransferase-like 5, SKB1Hs, SKB1, JBP1, IBP72, HRMT1L5, protein arginine methyltransferase 5)

Anti -PRMT5 (SKB1 homolog, HMT1 hnRNP methyltransferase-like 5, SKB1Hs, SKB1, JBP1, IBP72,
HRMT1L5, protein arginine methyltransferase 5)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified B
Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT5, also known as Janus kinase-binding protein 1 (JBP1) and Skb1Hs (human homolog of Skb1 of fission yeast can catalyze the formation of mega-N(G)-monomethylarginine and symmetric omega-N(G),N(G')-dimethylarginine in a variety of proteins. Recombinant PRMT5 can mono and dimethylate histone 2A and myelin basic protein. PRMT5 appears to have lower specific enzyme activity than PRMT1.
Catalog #P9004-26A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:16000
Western Blot: 1-3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid 0.5mg/ml Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified from goat serum by ammonium sulfate precipitation followed by antigen affinity chromatography using the immunizing peptide.
ImmunogenSynthetic peptide corresponding to RACREKDRDPEAQ, from the internal region of the protein sequence according to (NP_006100.2; NP_001034708.1.).
SpecificityRecognizes human PRMT5. Sequence Homology: mouse, rat, bovine, porcine, canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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