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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -PRMT6 (Protein Arginine Methyltransferase 6, Protein Arginine N-methyltransferase 6, FLJ10559, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-like Protein 6, HMT1 hnRNP Methyltransferase-like 6, HRMT1L6)

Anti -PRMT6 (Protein Arginine Methyltransferase 6, Protein Arginine N-methyltransferase 6,
FLJ10559, Heterogeneous Nuclear Ribonucleoprotein Methyltransferase-like Protein 6, HMT1
hnRNP Methyltransferase-like 6, HRMT1L6)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP
PRMT6 severely impairs the function of HIV-1 Rev.
PRMT6 is a protein arginine N-methyltransferase, and catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation is a prevalent post-translational modification in eukaryotic cells that has been implicated in signal transduction, the metabolism of nascent pre-RNA, and the transcriptional activation processes. In addition, PRMT6 displays automethylation activity; it is the first PRMT to do so. PRMT6 has been shown to act as a restriction factor for HIV replication.
Catalog #P9004-30C
ApplicationsSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormTris-citrate/phosphate buffer, pH 7 to 8
PurityPurified by immunoaffinity chromatography.
ImmunogenThe epitope recognized maps to a region between residue 325 and the C-terminus (residue 375) of human Protein Arginine Methyltransferase 6 using the numbering given in entry AAK85733.1 (GeneID 55170).
SpecificityThis antibody is specific to the human PRMT6 protein. Species Crossreactivity: Human. Other species have not been tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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