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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

Prohibitin is located in the inner membrane of the mitochondria. It is expressed in a variety of tissues. Prohibitin inhibits DNA synthesis and plays a role in regulating negative cell proliferation. It may also be a tumor suppressor. Mutations in prohibitin have been linked to sporadic breast cancer. However, it is not yet clear whether it is the protein itself or the associated mRNA that exhibits these effects. Prohibitin may also play a role in regulating mitochondrial respiration activity and in aging.
Catalog #	P9007-51D
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	ELISA: 0.05-0.2ug/ml
	Western Blot: 0.5-1ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a lyophilized powder in PBS, pH 7.4, 0.02% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide within residues 100-150 of human prohibitin protein (Swiss Prot: P35232).
Specificity	Recognizes endogenous levels of human prohibitin protein. Species sequence homology: mouse and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.