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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified E B

Prohibitin is believed to be a negative regulator of cell proliferation and may also act as a tumor suppressor. Mutations in prohibitin have been linked to sporadic breast cancer. Prohibitin inhibits DNA synthesis and plays a role in proliferation regulation. As yet, it is unclear if it is the protein or the mRNA that exhibits these effects. Prohibitin may play a role in regulating mitochondrial respiration activity and aging. Prohibitin is located at the inner mitochondrial membrane and is widely expressed in various tissues.
Catalog #	P9007-51E
Applications	Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution	ELISA: 0.05-0.2ug/ml
	Western Blot: 0.5-1ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	Lyophilized powder may be stored at -20°C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.5mg/ml
Form	Supplied as a lyophilized powder in PBS, pH 7.4, 0.02% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide (KLH). derived from within residues 50-100 of human prohibitin (Swiss Prot: P35232).
Specificity	Recognizes endogenous levels of human prohibitin protein.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.