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Specifications

Clone Host Grade Applications Monoclonal Mouse Purified IH

Prohibitin is an evolutionarily conserved gene with homologues found in organisms ranging from yeast to man. The gene was first identified in resting, mammalian cells. It has antiproliferative activity and is also involved in diverse processes as normal cell cycle regulation, replicative senescence and cellular immortalization. The 30kD protein has been located in the inner membrane of mitochondria, where it is postsynthetically modified, as well as on the plasma membrane of B cells, where it is associated with the IgM receptor. The protein is also found in the nucleus, where it has been reported to bind the retinoblastoma protein and function as a novel regulator of E2F activity. Mutations in the prohibitin gene cause sporadic breast tumors. In rats the protein inhibits entry into S phase of the mitotic cell cycle.
Catalog #	P9007-51K
Applications	Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution	Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100
	Optimal dilutions to be determined by the researcher.
Positive Control	Heart
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	11E325
Host	Mouse
Source	Rat
Concentration	As reported
Form	Supplied as a liquid, 0.05% sodium azide.
Purity	Purified
Immunogen	Recombinant corresponding to rat prohibitin protein. Cellular Localization: Cytoplasmic.
Specificity	Recognizes rat prohibitin. Species Crossreactivity: mouse and porcine.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.