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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IH

Proinsulin is a prohormone precursor to Insulin, made by the pancreas in response to increased blood sugar. Proinsulin is 39 amino acids longer than the mature Insulin, of which 4 are completely lost and the remaining 35 forms the C-peptide. The measurement of Proinsulin in serum provides a useful, valuable information for the diagnosis of insulinomas. Proinsulin levels have also been shown to be elevated in non-insulin dependent diabetics (NIDDM), in insulin dependent diabetics (IDDM) and other clinical situations. The antibody recognizes insulin and recombinant proinsulin, but does not react with synthetic C-peptide.
Catalog #	P9008-06F
Applications	Suitable for use in Indirect ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
	Indirect ELISA: 2ug/ml
	Immunohistochemistry: 20-40ug/ml
	Western Blot: 4-5ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	10g81
Host	Mouse
Concentration	~0.5mg/ml
Form	Supplied as a liquid in PBS, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Recombinant full length Insulin expressed in yeast
Specificity	Recognizes Proinsulin. Species crossreactivity: human, bovine and porcine.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.