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You are here:Home » Antibodies » Abs to Receptors » Anti -Prolactin Receptor (PRLR, PRL-R, PRL Receptor)

Anti -Prolactin Receptor (PRLR, PRL-R, PRL Receptor)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IP IH IC FC
Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor) which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription. Prolactin (PRL) is a hormone involved in a variety of important functions including ion transport and osmoregulation, stimulation of milk, protein synthesis as well as the regulation of numerous reproductive functions. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor, a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40kD to 100kD. The PRL receptor consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
Catalog #P9009-56G
Applications
Suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot and Immunoprecipitation. Other applications have not been tested.
Recommended Dilutions:
Immunocytochemistry: 5ug/ml
Immunohistochemistry: Frozen and paraffin sections
Western Blot: 1ug/ml, detects bands of ~40 and ~100kD representing both the short and the long forms of the prolactin receptor.
Immunofluorescence: 1:20
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6D695
HostMouse
SourceRat
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder, 0.05% sodium azide. Reconstitute with 100ul sterile PBS.
PurityPurified
ImmunogenPurified rat liver prolactin receptor.
SpecificityRecognizes the extracellular domain of rat prolactin receptor. Does not inhibit the interaction of prolactin with the receptor. Species Crossreactivity: human, rabbit and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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