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You are here:Home » Antibodies » Abs to Enzymes » Anti -Proprotein Convertase 9 (PC9, PCSK9, Neural Apoptosis-Regulated Convertase 1, NARC1)

Anti -Proprotein Convertase 9 (PC9, PCSK9, Neural Apoptosis-Regulated Convertase 1, NARC1)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B IP
Proprotein Convertase 9 encoded by the PCSK9 gene, (PC9 or NARC1 for neural apoptosis-regulated convertase-1), regulates cholesterol trafficking by controlling the plasma levels of LDL receptors. Different mutations in PCSK9 are associated with either elevated or reduced plasma levels of LDL-cholesterol. Human PCSK9 consists of a pro domain (aa29-152) and a mature chain (aa153-692).
Catalog #P9052-29
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Direct ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml. Using recombinant human propprotein convertase 9 under non-reducing conditions.
Immunoprecipitation: 25ug/ml immunoprecipitates recombinant human and mouse PC9 from conditioned cell medium.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypeMonoclonal
IsotypeIgG1
Clone No7H232
HostRat
SourceMouse
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa35-694 from mouse Proprotein Convertase 9 expressed in NSO cells (Q80W65).
Species Sequence HomologyRat/mouse-77%, chimpanzee-99%.
SpecificityRecognizes the mature form of mouse Proprotein Convertase 9 (PC9). Species Crossreactivity: human. Does not crossreact with recombinant human PC1 or PC7.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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