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You are here:Home » Antibodies » Abs to Prostaglandins » Anti -PTGDS (Lipocalin-type Prostaglandin-D Synthase, L-PGDS, Glutathione-independent PGD Synthetase, Prostaglandin-D2 Synthase, PGD2 Synthase, PGDS2, PGDS, Beta-trace Protein, Cerebrin-28)

Anti -PTGDS (Lipocalin-type Prostaglandin-D Synthase, L-PGDS, Glutathione-independent PGD
Synthetase, Prostaglandin-D2 Synthase, PGD2 Synthase, PGDS2, PGDS, Beta-trace Protein,
Cerebrin-28)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Prostaglandin D Synthase/Lipocalin (L-PGDS) is a brain-derived protein found most abundantly in CSF and it induces neuronal cell protection and neuronal cell loss, depending on the receptor pathway it signals to the target cells. L-PGDS is found secreted as well as localized to RER, nuclear membrane, Golgi apparatus, perinuclear cytoplasm etc and has been detected in arachnoid and menigioma cells, arachnoid trabecular cells, meningeal macrophages and perivascular microglial cells, oligodendrocytes as well as RPE cells. L-PGDS catalyzes the metabolic transformation of PGH2 to PGD2, a prostaglandin implicated in smooth muscle contraction/relaxation and a platelet aggregation inhibitor. It is implicated in several CNS functions including sedation, NREM sleep and PGE2-induced allodynia, and plays anti-apoptotic role in oligodendrocytes. L-PGDS can bind to small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. L-PGDS has also been suggested to play role in development and maintenance of blood-brain, blood-retina, blood-aqueous humor and blood-testis barriers.
Catalog #P9053-24D
ApplicationsSuitable for use in Western Blot. Other applications have not been tested.
Recommended DilutionsWestern Blot: 2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, 30% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to a region between aa120-190 of human PTGDS. Cellular Localization
SpecificityRecognizes human PTGDS at ~21kD. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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