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You are here:Home » Antibodies » Abs to Prostaglandins » Anti -Prostaglandin D Synthase, Lipocalin form (PGD Synthase, L-PGDS)

Anti -Prostaglandin D Synthase, Lipocalin form (PGD Synthase, L-PGDS)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin type enzyme (beta-trace) and the hematopoietic enzyme (1,2). Lipocalin-type PGDS (L-PGDS) is localized in the central nervous system, genital organs of various mammals, and the human heart (1,3-5). Patients with chronic renal failure and hypertension exhibit elevated amounts of L-PGDS in serum and urine (6). The L-PGDS has been identified as beta-trace, which is a major protein in the human cerebrospinal fluid (2,7). Human L-PGDS is a 190 amino acid protein and can be detected at 24-26kD by immunoblotting.
Catalog #P9053-24L
Applications
Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended Dilutions
Immunohistochemistry: 1:2000
Western Blot: 1:1000 Incubate for 1 hour at RT. Overnight incubations at 4ºC with greater dilutions have also produced optimal results.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant mouse lipocalin prostaglandin D synthase (L-PGDS).
SpecificityRecognizes mouse L-PGDS. Species Crossreactivity: human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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