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Anti -Prostaglandin D Synthase, Lipocalin form (PGD Synthase, L-PGDS)
Anti -Prostaglandin D Synthase, Lipocalin form (PGD Synthase, L-PGDS)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IH |
|
| Prostaglandin (PG) D synthase is present in neural tissues and cerebrospinal fluid (beta-trace). This enzyme belongs to the lipocalin family which consists of transporter proteins for lipophilic substances in the extracellular space. PGD synthase is found in retinal pigment epithelium, from where it is secreted into the interphotoreceptor matrix. | | | Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin type enzyme (beta-trace) and the hematopoietic enzyme.1,2 Lipocalin-type PGD synthase (L-PGD synthase) is localized in the central nervous system, genital organs of various mammals and the human heart.1,3,4,5 Patients with chronic renal failure and hypertension exhibit elevated amounts of L-PGD synthase in serum and urine.6 The L-PGD synthase has been identified as beta-trace, which is a major protein in the human cerebrospinal fluid.2,7. | | | Catalog # | P9053-24L | | Applications | | | Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilutions | | | Immunohistochemistry: 1:2000 | | Western Blot: 1:1000 Incubate for 1 hour at RT. Overnight incubations at 4ºC with greater dilutions have also produced optimal results. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | Not Determined | | Form | Supplied as a liquid, 0.02% sodium azide. | | Purity | Serum | | Immunogen | Recombinant mouse lipocalin prostaglandin D synthase (L-PGDS). | | Specificity | Recognizes mouse L-PGDS. Species crossreactivity: human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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