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Anti -Prostaglandin D Synthase, Hematopoietic form (PGD Synthase)
Anti -Prostaglandin D Synthase, Hematopoietic form (PGD Synthase)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IH |
|
| Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin-type enzyme (beta-trace) and the hematopoietic enzyme.1,2,3 Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as beta-trace, which is a major protein in human cerebrospinal fluid.4,2 Hematopoietic PGD synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes.1 This enzyme, which requires glutathione for activity, belongs to the sigma-class of Glutathione-S- Transferases and is approximately 23kD in size. | | | Catalog # | P9053-25K | | Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:200 1 hr at RT | | 1:500 Overnight incubation at 4ºC | | Immunohistochemistry: 1:1000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | Not Determined | | Form | Supplied as a liquid, 0.02% sodium azide | | Purity | Serum | | Immunogen | Recombinant mouse hematopoietic prostaglandin D synthase (H-PGDS). | | Specificity | Recognizes mouse hematopoietic prostaglandin D synthase. | | Species Crossreactivity | Human | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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