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You are here:Home » Antibodies » Abs to Prostaglandins » Anti -Prostaglandin D Synthase, Hematopoietic form (PGD Synthase)

Anti -Prostaglandin D Synthase, Hematopoietic form (PGD Synthase)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Purified B IH
Prostaglandin D synthase (PGD synthase) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin-type enzyme (b-trace) and the hematopoietic enzyme. Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as beta-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic PGD synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. This enzyme, which requires glutathione for activity, belongs to the sigma-class of glutathione S-transferases and is approximately 23kD in size.
Catalog #P9053-25P
ApplicationsSuitable for use in Immunohistochemistry and Western Blot. Other applications not tested.
Recommended Dilutions
Immunohistochemistry: 1:1000-1:5000
Western Blot: 1:1000. Incubate for 1 hour at RT or overnight at 4°C for optimal results..
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No6D697
HostRat
SourceMouse
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide, 50% glycerol.
PurityPurified
ImmunogenRecombinant protein corresponding to mouse hematopoietic prostaglandin D synthase (H-PGDS).
SpecificityRecognizes mouse H-PGDS. Species Crossreactivity: human.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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