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You are here:Home » Antibodies » Abs to Prostaglandins » Anti -Prostaglandin J2, 15-deoxy-D12,14-

Anti -Prostaglandin J2, 15-deoxy-D12,14-

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E
15-deoxy-Delta12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2, formed via the intermediate Delta12-PGJ2. 15-d-PGJ2 is physiologically present in body fluids at concentration of 10-12 to 10-9 M, but increases dramatically under stress such as infection and inflammation. 15-d-PGJ2 exerts both pro- and anti-inflammatory effects in a cell-type and concentration-dependent manner, with many of these effects mediated via binding to the gamma isoform of the peroxisome proliferators-activated receptor (PPAR-gamma). 15-d-PGJ2 appears to induce HO-1 expression by a PPAR-gamma-independent mechanism mediated by the generation of reactive oxygen species (ROS).
Catalog #P9053-35B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration1mg/ml
FormSupplied as a liquid in PBS, 0.1% sodium azide.
PurityPurified by sodium sulfate precipitation.
Immunogen15-deoxy-D12,14-PGJ2 conjugated to a protein carrier molecule.
SpecificityRecognizes Prostaglandin J2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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