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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B IH

Prostaglandin I Synthase catalyzes the isomerization of PGH2 to PGI2 (prostacyclin). PGI2 is a potent vasodilator and inhibitor of platelet aggregation. PGIS is a membrane-bound hemoprotein localized primarily in endothelial cells. The cloned bovine and human enzymes contain 500aa and calculated molecular mass of 56,629 and 57,103, respectively. Northern blot analysis reveals that the mRNA for PGIS is expressed in a wide variety of human tissues and is particularly abundant in ovary, heart, skeletal muscle, prostate and lung.
Catalog #	P9053-39
Applications
	Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions	Western Blot: 1:250
	Immunohistochemistry: 1:250
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Mouse
Concentration	~0.5mg/ml
Form	Supplied as a liquid in TBS, pH 7.4, 0.1% BSA, 0.02% sodium azide, 50% glycerol.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide corresponding to aa475-490 (PEFDLSRYGFGLMQPE) of mouse Prostaglandin I Synthase (PGIS). Species Sequence Homolgy: Human, bovine and rat - 100%
Specificity	Recognizes mouse PGIS. Other species have not been tested. Species Crossreactivity: human, bovine, ovine and rat.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.