Anti -PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S
Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding
Protein 7, TBP-7, MIP224, TBP7) (Azide Free)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH IC IF |
|
| The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. | | | Catalog # | P9078-26A | | Applications | Suitable for use in ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1ug/ml-3ng/ml | | Western Blot: 1:500-1:1000 | | Immunohistochemistry (Paraffin): 1.5ug/ml | | Immunofluorescence (IC): 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a,k | | Clone No | 11C606 | | Host | Mouse | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free). | | Purity | Purified by affinity chromatography. | | Immunogen | Full length recombinant protein corresponding to aa1-419 from human PSMC4 with GST tag. MW of GST alone is 26kD. | | Specificity | Recognizes human PSMC4. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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