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You are here:Home » Antibodies » Abs to Proteasomes » Anti -PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding Protein 7, TBP-7, MIP224, TBP7) (Azide Free)

Anti -PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S
Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding
Protein 7, TBP-7, MIP224, TBP7) (Azide Free)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH IC IF
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
Catalog #P9078-26A
ApplicationsSuitable for use in ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1ug/ml-3ng/ml
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 1.5ug/ml
Immunofluorescence (IC): 10ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No11C606
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
PurityPurified by affinity chromatography.
ImmunogenFull length recombinant protein corresponding to aa1-419 from human PSMC4 with GST tag. MW of GST alone is 26kD.
SpecificityRecognizes human PSMC4.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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