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You are here:Home » Antibodies » Abs to Proteasomes » Anti -Proteasome 26S Non-ATPase Subunit 2 (Proteasome (Prosome, Macropain) 26S Subunit Non-ATPase 2, Proteasome 26S Subunit Non-ATPase 2, PSMD2, 26S Proteasome Non-ATPase Regulatory Subunit 2, 26S Proteasome Regulatory Subunit RPN1, 26S Proteasome Regulatory Su

Anti -Proteasome 26S Non-ATPase Subunit 2 (Proteasome (Prosome, Macropain) 26S Subunit
Non-ATPase 2, Proteasome 26S Subunit Non-ATPase 2, PSMD2, 26S Proteasome Non-ATPase
Regulatory Subunit 2, 26S Proteasome Regulatory Subunit RPN1, 26S Proteasome Regulatory Su

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. 26S S2 is one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1
Catalog #P9078-45J
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide: C VILRKNPNYDL, representing the C-terminus of the human protein (residues 898-908), according to NP_002799.
SpecificitySpecies Crossreactivity: Reacts with Human. Predicted to react with Mouse (100% identity with immunogen), Crab Eating Macaque Monkey (100% identity with immunogen) , Orangutan (100% identity with immunogen) and porcine (100% identity with immunogen) due to sequence homology.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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