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You are here:Home » Antibodies » Abs to Protein C » Anti -Activated Protein C (APC)

Anti -Activated Protein C (APC)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified E B
Protein C (PC) is an important regulator of the blood coagulation system. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM)–thrombin complex on the phospholipid surface of endothelial cells, monocytes, and platelets. This process is enhanced in the presence of the endothelial protein C receptor (EPCR). In addition to its regulatory function in the blood coagulation system, studies indicate important roles for APC in inflammatory processes. The administration of APC prevents lethal effects of Escherichia coli–associated sepsis in experimental animal models and appears effective for the treatment of patients with meningococcemia or acquired PC deficiency. Treatment with APC improves the clinical outcome of patients with sepsis. The anti-inflammatory activity of APC depends on its ability to suppress the secretion of cytokines as tumor necrosis factor-alpha by inflammatory cells, the activation and extravasation of leukocytes and the expression and function of adhesion molecules. APC may also suppress the expression of growth factors and members of nuclear factor-kB (NF-kB) family of transcription factors.
Catalog #P9102-39A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:50
Western Blot: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone NoPC107
HostRat
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
SpecificityRecognizes activated human protein C (APC) and lacks reactivity for Protein C (PC). Recognizes the light chain of the APC molecule.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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