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Anti -Protein Gene Product 9.5 (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin Thiolesterase, PARK5)
Anti -Protein Gene Product 9.5 (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin
Thiolesterase, PARK5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
B IH |
|
| PGP9.5 is a soluble cytoplasmic protein with a molecular weight of approximately 25kD. It is present in neurons and in cells of the diffuse neuroendocrine system. PGP9.5 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as UCH-L1. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers. It was also discovered as a gene mutated in some rare famial forms of Parkinson's disease. Interestingly a common allelic variant of UCH-L1, the S18Y polymorphism is actually protective against Parkinson's disease. It is also a marker for cells of the diffuse neuroendocrine system and their tumors. | | | Catalog # | P9102-70G | | Applications | Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. | | Recommended Dilution | Immunohistochemistry: 1:500-1:1000 | | Western Blot: 1:1000-1:2000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding to amino acids 176-191 (ASSEDTLLKDAAKVCR) of human PGP9.5. | | Specificity | Recognizes human PGP9.5. Species Crossreactivity: mouse, rat and porcine. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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