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You are here:Home » Antibodies » Abs to Ubiquitin » Anti -Protein Gene Product 9.5 (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin thiolesterase, PARK5)

Anti -Protein Gene Product 9.5 (PGP9.5, Ubiquitin CT Hydrolase L1, UCH, UCHL1, Ubiquitin
thiolesterase, PARK5)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Protein ubiquitination and deubiquitination is a reversible process catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (DUBs). DUBs are categorized into 5 subfamilies USP, UCH, OTU, MJD and JAMM. UCHL1 and UCHL3 belong to the UCH family of DUBs. UCHL1 is abundantly expressed in neuronal tissues and testes, while UCHL3 is more widely distributed. UCHL1 binds monoubiquitin and UCHL3 shows affinity to both ubiquitin and NEDD8, a ubiquitin-like molecule. Both enzymes play a role in the regulation of neuronal development and spermatogenesis and have been implicated in neurodegenerative diseases.
Catalog #P9102-70J
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
PurityPurified by peptide affinity chromatography.
ImmunogenSynthetic peptide corresponding to residues surrounding Asp110 of the human Protein Gene Product 9.5.
SpecificityRecognizes endogenous levels of total human Protein Gene Product 9.5 at ~27kD. Species Crossreactivity: mouse, rat and monkey
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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