Anti -Protein Gene Product 9.5 (PGP9.5, PGP-9.5, Gracile Axonal Dystrophy, Neuron
Cytoplasmic Protein 9.5, Parkinson Disease 5, Park5, Ubiquitin Carboxyl Terminal Esterase
L1, Ubiquitin C-terminal Esterase L1, Ubiquitin Carboxyl Terminal Hydrolase Isozyme L1, U
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Chicken |
Purified |
B IF |
|
| PGP9.5/UCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Protein gene product (PGP9.5) is a neuron specific protein, structurally and immunologically distinct from neuron specific enolase. The protein which has a molecular weight of 27kD was first identified by high resolution two dimensional PAGE. Standard immunohistochemical techniques have demonstrated the presence of PGP9.5 in neurons and nerve fibers at all levels of the central and peripheral nervous system, in many neuroendocrine cells, in segments of the renal tubules, in spermatogonia and Leydig cells of the testis, in ova and in some cells of both the pregnant and non-pregnant corpus luteum. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. | | | Catalog # | P9102-70Z | | Applications | Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. | | Recommended Dilutions | Immunofluorescence (IC): 1:1000 | | Western Blot: 1:10,000 | | Optimal dilutions to be determined by the researcher. | | Recommended Secondary Antibodies | I1906: IgY, Chicken Pab Rb x Ch | | I1906-10: IgY, Chicken (HRP) Rb x Ch | | I1906-12: IgY, Chicken (FITC) Rb x Ch | | I1906-14: IgY, Chicken (AP) Rb x Ch | | Positive Control | Rat spinal cord or peripheral nerve homogenate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgY | | Host | Chicken | | Source | Human | | Concentration | Not Determined | | Form | Supplied as a liquid in PBS, 10mM sodium azide. | | Purity | Purified by ammonium sulfate precipitation | | Immunogen | Recombinant corresponding to full length human Protein Gene Product 9.5 purified from E. coli. | | Specificity | Recognizes human PGP9.5 at ~27kD. Species Crossreactivity: rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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