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You are here:Home » Antibodies » Abs to Enzymes, Phosphatase » Anti -PPM1A (Protein Phosphatase 2C alpha, PP2Ca, Protein Phosphatase 1A, Protein Phosphatase 2C Isoform alpha, PP2C-alpha, Protein Phosphatase IA, PPPM1A)

Anti -PPM1A (Protein Phosphatase 2C alpha, PP2Ca, Protein Phosphatase 1A, Protein
Phosphatase 2C Isoform alpha, PP2C-alpha, Protein Phosphatase IA, PPPM1A)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Protein phosphatase 2C alpha (PP2C-alpha) dephosphorylates proteins with some preference for phosphor-threonine over phospho-serine residues. It is insensitive to PP1 and PP2a inhibitors such as okadaic acid, but has an absolute requirement for either magnesium or manganese ions. PP2c-alpha and can be activated by unsaturated fatty acids, such as arachidonic and oleic acid. Overexpression of PP2C-alpha causes G2/M cell cycle arrest and apoptosis that has been associated with the activation of p53. Dephosphorylation of proteins in the nucleus by PP2C-aplha is suspected to play a role in terminating or reducing the sensitivity of the responses to SMADs and stress-activated proteins such as p38 and JNK.
Catalog #P9107-13E
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11C45
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenE.coli-derived recombinant human PP2C-alpha (rhPP2C-alpha; aa1-324; Accession # P35813).
SpecificityRecognizes human PP2Ca. Species Crossreactivity: mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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